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Target
Transcriptional enhancer factor TEF-3
Ligand
BDBM50531838
Substrate
n/a
Meas. Tech.
ChEMBL_1921068 (CHEMBL4423913)
IC50
36000±n/a nM
Citation
 Smith, SA; Sessions, RB; Shoemark, DK; Williams, C; Ebrahimighaei, R; McNeill, MC; Crump, MP; McKay, TR; Harris, G; Newby, AC; Bond, M Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking. J Med Chem 62:1291-1305 (2019) [PubMed]  Article 
Target
Name:
Transcriptional enhancer factor TEF-3
Synonyms:
RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3
Type:
PROTEIN
Mol. Mass.:
48333.01
Organism:
Homo sapiens
Description:
ChEMBL_118073
Residue:
434
Sequence:
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
  
Inhibitor
Name:
BDBM50531838
Synonyms:
Pirazidol | Pirlindole
Type:
Small organic molecule
Emp. Form.:
C15H18N2
Mol. Mass.:
226.3168
SMILES:
Cc1ccc2n3CCNC4CCCc(c34)c2c1
Structure:
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