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Target
Transcriptional enhancer factor TEF-1
Ligand
BDBM50531838
Substrate
n/a
Meas. Tech.
ChEMBL_1921065 (CHEMBL4423910)
IC50
40000±n/a nM
Citation
 Smith, SA; Sessions, RB; Shoemark, DK; Williams, C; Ebrahimighaei, R; McNeill, MC; Crump, MP; McKay, TR; Harris, G; Newby, AC; Bond, M Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking. J Med Chem 62:1291-1305 (2019) [PubMed]  Article 
Target
Name:
Transcriptional enhancer factor TEF-1
Synonyms:
NTEF-1 | Protein GT-IIC | TCF-13 | TCF13 | TEA domain family member 1 | TEAD-1 | TEAD1 | TEAD1_HUMAN | TEF1 | Transcription factor 13 | Transcriptional enhancer factor TEF-1
Type:
PROTEIN
Mol. Mass.:
47954.57
Organism:
Homo sapiens
Description:
ChEMBL_109666
Residue:
426
Sequence:
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
  
Inhibitor
Name:
BDBM50531838
Synonyms:
Pirazidol | Pirlindole
Type:
Small organic molecule
Emp. Form.:
C15H18N2
Mol. Mass.:
226.3168
SMILES:
Cc1ccc2n3CCNC4CCCc(c34)c2c1
Structure:
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