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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50537705
Substrate
n/a
Meas. Tech.
ChEMBL_1970368 (CHEMBL4603186)
IC50
178000±n/a nM
Citation
 Tomohara, K; Hasegawa, N; Adachi, I; Horino, Y; Nose, T Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50537705
Synonyms:
CHEMBL4640749
Type:
Small organic molecule
Emp. Form.:
C15H20N6O4
Mol. Mass.:
348.3571
SMILES:
Cn1cnc2n(C)c(=O)n(CCCCC3(C)NC(=O)NC3=O)c(=O)c12
Structure:
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