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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50095053
Substrate
n/a
Meas. Tech.
ChEMBL_2311 (CHEMBL617518)
Ki
1.20±n/a nM
Citation
 Crawforth, J; Goodacre, S; Maxey, R; Bourrain, S; Patel, S; Marwood, R; O'Connor, D; Herbert, R; Hutson, P; Rowley, M 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. Bioorg Med Chem Lett 10:2701-3 (2000) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50095053
Synonyms:
3-[1-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-piperidin-4-yl]-2-phenyl-1H-indole | CHEMBL330482
Type:
Small organic molecule
Emp. Form.:
C34H39N3
Mol. Mass.:
489.6936
SMILES:
C(Cc1ccccc1)N1C2CCC1CC(C2)N1CCC(CC1)c1c([nH]c2ccccc12)-c1ccccc1 |TLB:0:8:14.13.15:10.11,THB:16:14:8:10.11|
Structure:
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