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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50539663
Substrate
n/a
Meas. Tech.
ChEMBL_1978553 (CHEMBL4611688)
IC50
960±n/a nM
Citation
 Davidsson, Ö; Nilsson, K; Brånalt, J; Andersson, T; Berggren, K; Chen, Y; Fjellström, O; Gradén, H; Gustafsson, L; Hermansson, NO; Jansen, F; Johannesson, P; Ohlsson, B; Tyrchan, C; Wellner, A; Wellner, E; Ölwegård-Halvarsson, M Identification of novel GPR81 agonist lead series for target biology evaluation. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50539663
Synonyms:
CHEMBL4632411
Type:
Small organic molecule
Emp. Form.:
C27H33ClN6O4S
Mol. Mass.:
573.107
SMILES:
CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2ccc(CN3CCN(C)CC3)cc2s1
Structure:
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