Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM218202
Substrate
n/a
Meas. Tech.
ChEMBL_1982473 (CHEMBL4615735)
IC50
6860±n/a nM
Citation
 Shen, S; Svoboda, M; Zhang, G; Cavasin, MA; Motlova, L; McKinsey, TA; Eubanks, JH; Ba?inka, C; Kozikowski, AP Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor. ACS Med Chem Lett 11:706-712 (2020) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
HD1 | HDAC1_MOUSE | Hdac1 | Histone deacetylase 1/2
Type:
Protein
Mol. Mass.:
55062.26
Organism:
Mus musculus (Mouse)
Description:
O09106
Residue:
482
Sequence:
MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM218202
Synonyms:
US9249087, 43
Type:
Small organic molecule
Emp. Form.:
C11H11N3O2
Mol. Mass.:
217.2239
SMILES:
ONC(=O)c1ccc(Cn2cccn2)cc1
Structure:
Search PDB for entries with ligand similarity: