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Target
Fusion glycoprotein F0
Ligand
BDBM50541843
Substrate
n/a
Meas. Tech.
ChEMBL_1985450 (CHEMBL4618856)
EC50
6.2±n/a nM
Citation
 Yamaguchi-Sasaki, T; Tokura, S; Ogata, Y; Kawaguchi, T; Sugaya, Y; Takahashi, R; Iwakiri, K; Abe-Kumasaka, T; Yoshida, I; Arikawa, K; Sugiyama, H; Kanuma, K Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins. ACS Med Chem Lett 11:1145-1151 (2020) [PubMed]  Article 
Target
Name:
Fusion glycoprotein F0
Synonyms:
F | Fusion glycoprotein F0
Type:
PROTEIN
Mol. Mass.:
63485.30
Organism:
Human respiratory syncytial virus
Description:
ChEMBL_106144
Residue:
574
Sequence:
MELPILKANAITTILAAVTFCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLMKQELDKYKNAVTELQLLMQSTPAANNRARRELPRFMNYTLNNTKKTNVTLSKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCRISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
  
Inhibitor
Name:
BDBM50541843
Synonyms:
CHEMBL4641371
Type:
Small organic molecule
Emp. Form.:
C28H39N7O2
Mol. Mass.:
505.655
SMILES:
CC[C@@H]1N(C)C(=O)c2cc(C)ccc2OCCCCCN(C)c2cc(nc3cc1nn23)N1CC[C@H](N)C1 |r|
Structure:
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