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Target
Fusion glycoprotein F0
Ligand
BDBM50541848
Substrate
n/a
Meas. Tech.
ChEMBL_1985451 (CHEMBL4618857)
EC50
8.1±n/a nM
Citation
 Yamaguchi-Sasaki, T; Tokura, S; Ogata, Y; Kawaguchi, T; Sugaya, Y; Takahashi, R; Iwakiri, K; Abe-Kumasaka, T; Yoshida, I; Arikawa, K; Sugiyama, H; Kanuma, K Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins. ACS Med Chem Lett 11:1145-1151 (2020) [PubMed]  Article 
Target
Name:
Fusion glycoprotein F0
Synonyms:
F | FUS_HRSVA | Fusion glycoprotein F0 | Fusion glycoprotein F1 | Fusion glycoprotein F2 | Intervening segment | Pep27 | Peptide 27 | p27
Type:
PROTEIN
Mol. Mass.:
63471.29
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_116942
Residue:
574
Sequence:
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPPTNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEINLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGMDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
  
Inhibitor
Name:
BDBM50541848
Synonyms:
CHEMBL4640616
Type:
Small organic molecule
Emp. Form.:
C28H37N7O2
Mol. Mass.:
503.6391
SMILES:
CN1CCCCOc2ccc(C)cc2C(=O)N2CCCC[C@H]2c2cc3nc(cc1n3n2)N1CC[C@H](N)C1 |r|
Structure:
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