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Target
Coagulation factor VII
Ligand
BDBM50543898
Substrate
n/a
Meas. Tech.
ChEMBL_1990662 (CHEMBL4624397)
IC50
1000±n/a nM
Citation
 Jayne, CL; Andreani, T; Chan, TY; Chelliah, MV; Clasby, MC; Dwyer, M; Eagen, KA; Fried, S; Greenlee, WJ; Guo, Z; Hawes, B; Hruza, A; Ingram, R; Keertikar, KM; Neelamkavil, S; Reichert, P; Xia, Y; Chackalamannil, S Discovery of hydroxy pyrimidine Factor IXa inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50543898
Synonyms:
CHEMBL4636716
Type:
Small organic molecule
Emp. Form.:
C18H17N5O
Mol. Mass.:
319.3605
SMILES:
Cc1ccc(cc1)-c1ncnc(Nc2ccc(cc2)C(N)=N)c1O
Structure:
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