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Target
Tumor necrosis factor ligand superfamily member 11
Ligand
BDBM50547334
Substrate
n/a
Meas. Tech.
ChEMBL_2017728 (CHEMBL4671306)
IC50
2860±n/a nM
Citation
 Rinotas, V; Papakyriakou, A; Violitzi, F; Papaneophytou, C; Ouzouni, MD; Alexiou, P; Strongilos, A; Couladouros, E; Kontopidis, G; Eliopoulos, E; Douni, E Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-?B Ligand with a Superior Therapeutic Index. J Med Chem 63:12043-12059 (2020) [PubMed]  Article 
Target
Name:
Tumor necrosis factor ligand superfamily member 11
Synonyms:
CD_antigen=CD254 | ODF | OPGL | RANKL | TNF11_HUMAN | TNFSF11 | TRANCE
Type:
PROTEIN
Mol. Mass.:
35484.75
Organism:
Homo sapiens
Description:
ChEMBL_106141
Residue:
317
Sequence:
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
  
Inhibitor
Name:
BDBM50547334
Synonyms:
CHEMBL3741720
Type:
Small organic molecule
Emp. Form.:
C29H25N3O6S
Mol. Mass.:
543.59
SMILES:
CN(CCN(C)C(=O)c1coc2ccccc2c1=O)C(=O)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Structure:
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