Reaction Details Report a problem with these data
Target
Tumor necrosis factor ligand superfamily member 11
Ligand
BDBM50547340
Substrate
n/a
Meas. Tech.
ChEMBL_2017728 (CHEMBL4671306)
IC50
5100±n/a nM
Citation
 Rinotas, V; Papakyriakou, A; Violitzi, F; Papaneophytou, C; Ouzouni, MD; Alexiou, P; Strongilos, A; Couladouros, E; Kontopidis, G; Eliopoulos, E; Douni, E Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-?B Ligand with a Superior Therapeutic Index. J Med Chem 63:12043-12059 (2020) [PubMed]  Article 
Target
Name:
Tumor necrosis factor ligand superfamily member 11
Synonyms:
CD_antigen=CD254 | ODF | OPGL | RANKL | TNF11_HUMAN | TNFSF11 | TRANCE
Type:
PROTEIN
Mol. Mass.:
35484.75
Organism:
Homo sapiens
Description:
ChEMBL_106141
Residue:
317
Sequence:
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
  
Inhibitor
Name:
BDBM50547340
Synonyms:
CHEMBL4752672
Type:
Small organic molecule
Emp. Form.:
C26H21N5O7S2
Mol. Mass.:
579.604
SMILES:
[O-][N+](=O)c1cccc(c1)S(=O)(=O)n1cc(C(=O)N2CCN(CC2)S(=O)(=O)c2ccc(cc2)C#N)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: