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Target
Thyroid hormone receptor beta
Ligand
BDBM50108808
Substrate
n/a
Meas. Tech.
ChEMBL_210500 (CHEMBL811895)
IC50
4000±n/a nM
Citation
 Carlsson, B; Singh, BN; Temciuc, M; Nilsson, S; Li, YL; Mellin, C; Malm, J Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone. J Med Chem 45:623-30 (2002) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:
Receptor
Mol. Mass.:
52793.62
Organism:
Homo sapiens (Human)
Description:
Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:
461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM50108808
Synonyms:
CHEMBL160703 | [4-(2-Butyl-benzofuran-3-carbonyl)-2,6-diiodo-phenoxy]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C21H18I2O5
Mol. Mass.:
604.1736
SMILES:
CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCC(O)=O)c(I)c1
Structure:
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