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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50553467
Substrate
n/a
Meas. Tech.
ChEMBL_2046597 (CHEMBL4701296)
IC50
>100000±n/a nM
Citation
 Radwan, MO; Ciftci, HI; Ali, TFS; Koga, R; Tateishi, H; Nakata, A; Ito, A; Yoshida, M; Fujita, M; Otsuka, M Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50553467
Synonyms:
CHEMBL4782892
Type:
Small organic molecule
Emp. Form.:
C30H31ClN2S
Mol. Mass.:
487.099
SMILES:
CN(C)c1ccc(CNCCSC(c2ccccc2)(c2ccccc2)c2ccccc2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: