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Target
Kappa-type opioid receptor
Ligand
BDBM50120404
Substrate
n/a
Meas. Tech.
ChEMBL_146681 (CHEMBL753172)
Ki
228.0±n/a nM
Citation
 Iadanza, M; Höltje, M; Ronsisvalle, G; Höltje, HD Kappa-opioid receptor model in a phospholipid bilayer: molecular dynamics simulation. J Med Chem 45:4838-46 (2002) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50120404
Synonyms:
Acetic acid 2-(8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-ylmethyl)-1-phenyl-cyclopropylmethyl ester | CHEMBL436608
Type:
Small organic molecule
Emp. Form.:
C27H33NO3
Mol. Mass.:
419.5558
SMILES:
C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2CC1C[C@@]1(COC(C)=O)c1ccccc1 |TLB:9:10:1:15.13.14,THB:16:15:1:10.4.3|
Structure:
Search PDB for entries with ligand similarity: