Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50125251
Substrate
n/a
Meas. Tech.
ChEBML_212863
Ki
>5200±n/a nM
Citation
 Quan, ML; Ellis, CD; He, MY; Liauw, AY; Lam, PY; Rossi, KA; Knabb, RM; Luettgen, JM; Wright, MR; Wong, PC; Wexler, RR Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors. Bioorg Med Chem Lett 13:1023-8 (2003) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50125251
Synonyms:
3-(3-Amino-benzo[d]isoxazol-5-yl)-5-(methanesulfonylamino-methyl)-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide | CHEMBL8018
Type:
Small organic molecule
Emp. Form.:
C24H23N7O7S2
Mol. Mass.:
585.612
SMILES:
CS(=O)(=O)NCC1(CC(=NO1)c1ccc2onc(N)c2c1)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O |c:8|
Structure:
Search PDB for entries with ligand similarity: