Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50206434
Substrate
n/a
Meas. Tech.
ChEMBL_2105310 (CHEMBL4813813)
IC50
>100000±n/a nM
Citation
 Kitakami, R; Inui, K; Nakagawa, Y; Sawai, Y; Katayama, W; Yokoyama, T; Okada, T; Kanamitsu, K; Nakagawa, S; Toyooka, N; Mizuguchi, M Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg Med Chem 44:0 (2021) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50206434
Synonyms:
1,2-Anthraquinonediol | 1,2-dihydroxy-9,10-anthraquinone | 1,2-dihydroxyanthra-9,10-quinone | 1,2-dihydroxyanthracene-9,10-dione | Alizarin B | Alizarin Red | CHEMBL55814 | Turkey Red | US20230364057, Compound 256 | alizarin
Type:
Small organic molecule
Emp. Form.:
C14H8O4
Mol. Mass.:
240.2109
SMILES:
Oc1ccc2C(=O)c3ccccc3C(=O)c2c1O
Structure:
Search PDB for entries with ligand similarity: