Reaction Details Report a problem with these data
Target
Leukotriene B4 receptor 1
Ligand
BDBM50136724
Substrate
n/a
Meas. Tech.
ChEMBL_99664 (CHEMBL704430)
IC50
400±n/a nM
Citation
 McKew, JC; Lovering, F; Clark, JD; Bemis, J; Xiang, Y; Shen, M; Zhang, W; Alvarez, JC; Joseph-McCarthy, D Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics. Bioorg Med Chem Lett 13:4501-4 (2003) [PubMed]  Article 
Target
Name:
Leukotriene B4 receptor 1
Synonyms:
BLT | BLT1 | BLTR | CMKRL1 | Chemoattractant receptor-like 1 | G-protein coupled receptor 16 | GPR16 | LT4R1_HUMAN | LTB4-R 1 | LTB4R | Leukotriene B4 R1 | Leukotriene B4 receptor | Leukotriene B4 receptor 1 | P2RY7 | P2Y purinoceptor 7 | P2Y7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37582.68
Organism:
Homo sapiens (Human)
Description:
Q15722
Residue:
352
Sequence:
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
  
Inhibitor
Name:
BDBM50136724
Synonyms:
4-(1-Benzhydryl-5-methyl-1H-indol-3-ylmethyl)-3-methoxy-benzoic acid | CHEMBL337790
Type:
Small organic molecule
Emp. Form.:
C31H27NO3
Mol. Mass.:
461.551
SMILES:
COc1cc(ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12)C(O)=O
Structure:
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