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Target
Methionine--tRNA ligase
Ligand
BDBM50149623
Substrate
n/a
Meas. Tech.
ChEMBL_305245 (CHEMBL833503)
IC50
3.8±n/a nM
Citation
 Jarvest, RL; Armstrong, SA; Berge, JM; Brown, P; Elder, JS; Brown, MJ; Copley, RC; Forrest, AK; Hamprecht, DW; O'Hanlon, PJ; Mitchell, DJ; Rittenhouse, S; Witty, DR Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues. Bioorg Med Chem Lett 14:3937-41 (2004) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase
Synonyms:
Methionyl-tRNA synthetase | SYM_STAAW | metG | metS
Type:
PROTEIN
Mol. Mass.:
74852.92
Organism:
Staphylococcus aureus (strain MW2)
Description:
ChEMBL_305245
Residue:
657
Sequence:
MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPATEEEKEEIPSKPQIDIKDFDKVEIKAATIINAEHVKKSDKLLKIQVDLDSEQRQIVSGIAKFYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
  
Inhibitor
Name:
BDBM50149623
Synonyms:
CHEMBL424799 | N-(1H-Benzoimidazol-2-yl)-N''-(3-bromo-5-chloro-2-ethoxy-benzyl)-propane-1,3-diamine
Type:
Small organic molecule
Emp. Form.:
C19H22BrClN4O
Mol. Mass.:
437.761
SMILES:
CCOc1c(Br)cc(Cl)cc1CNCCCNc1nc2ccccc2[nH]1
Structure:
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