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Target
Methionine--tRNA ligase
Ligand
BDBM50149643
Substrate
n/a
Meas. Tech.
ChEMBL_305245 (CHEMBL833503)
IC50
6.2±n/a nM
Citation
 Jarvest, RL; Armstrong, SA; Berge, JM; Brown, P; Elder, JS; Brown, MJ; Copley, RC; Forrest, AK; Hamprecht, DW; O'Hanlon, PJ; Mitchell, DJ; Rittenhouse, S; Witty, DR Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues. Bioorg Med Chem Lett 14:3937-41 (2004) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase
Synonyms:
Methionyl-tRNA synthetase | SYM_STAAW | metG | metS
Type:
PROTEIN
Mol. Mass.:
74852.92
Organism:
Staphylococcus aureus (strain MW2)
Description:
ChEMBL_305245
Residue:
657
Sequence:
MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPATEEEKEEIPSKPQIDIKDFDKVEIKAATIINAEHVKKSDKLLKIQVDLDSEQRQIVSGIAKFYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
  
Inhibitor
Name:
BDBM50149643
Synonyms:
6-[3-(3,5-Dibromo-benzylamino)-propylamino]-7H-thieno[2,3-b]pyridin-4-one | CHEMBL368875
Type:
Small organic molecule
Emp. Form.:
C17H17Br2N3OS
Mol. Mass.:
471.209
SMILES:
Oc1cc(NCCCNCc2cc(Br)cc(Br)c2)nc2sccc12
Structure:
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