Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50150674
Substrate
n/a
Meas. Tech.
ChEMBL_302905 (CHEMBL830366)
Ki
1210±n/a nM
Citation
 Holmberg, P; Sohn, D; Leideborg, R; Caldirola, P; Zlatoidsky, P; Hanson, S; Mohell, N; Rosqvist, S; Nordvall, G; Johansson, AM; Johansson, R Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists. J Med Chem 47:3927-30 (2004) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50150674
Synonyms:
CHEMBL361875 | [(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C24H33NO2
Mol. Mass.:
367.5243
SMILES:
CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1c(OC)cccc1OC |wD:7.6,(2.5,-6.14,;2.29,-4.62,;3.51,-3.66,;3.3,-2.15,;4.44,-1.12,;5.91,-1.61,;7.07,-.59,;1.8,-1.75,;1.8,-.22,;.47,.58,;-.86,-.17,;-.86,-1.73,;.47,-2.5,;-2.18,-2.5,;-3.49,-1.73,;-3.49,-.17,;-2.18,.58,;-2.18,2.12,;-3.51,2.87,;-4.85,2.09,;-4.83,.54,;-3.56,4.41,;-2.21,5.19,;-.88,4.43,;-.86,2.92,;.47,2.16,;1.8,2.95,)|
Structure:
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