Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50589554
Substrate
n/a
Meas. Tech.
ChEMBL_2193756 (CHEMBL5106116)
Ki
5.5±n/a nM
Citation
 Beerkens, BLH; Wang, X; Avgeropoulou, M; Adistia, LN; van Veldhoven, JPD; Jespers, W; Liu, R; Heitman, LH; IJzerman, AP; van der Es, D Development of subtype-selective covalent ligands for the adenosine A RSC Med Chem 13:850-856 (2022) [PubMed] 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50589554
Synonyms:
CHEMBL5205220
Type:
Small organic molecule
Emp. Form.:
C14H13FN4O5S
Mol. Mass.:
368.34
SMILES:
CCCn1c(=O)[nH]c2nc([nH]c2c1=O)-c1ccc(OS(F)(=O)=O)cc1
Structure:
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