Reaction Details Report a problem with these data
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50595092
Substrate
n/a
Meas. Tech.
ChEMBL_2215386 (CHEMBL5128518)
IC50
170±n/a nM
Citation
 Wang, Y; Chen, H; Zha, X Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50595092
Synonyms:
CHEMBL5182719
Type:
Small organic molecule
Emp. Form.:
C30H30N8O4S2
Mol. Mass.:
630.74
SMILES:
CCn1c2nc(SSc3nc4n(CC)c(=O)n(CCc5ccccc5)c(=O)c4[nH]3)[nH]c2c(=O)n(CCc2ccccc2)c1=O
Structure:
Search PDB for entries with ligand similarity: