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Target
G-protein coupled receptor 39
Ligand
BDBM50596614
Substrate
n/a
Meas. Tech.
ChEMBL_2221582 (CHEMBL5134916)
EC50
15±n/a nM
Citation
 Burley, R; Hewer, RC; Teall, M; Dickson, L; Ossola, B; Russell, S; Bender, C; Cheung, T; Powell, JAC; Xu, X; Brice, NL; Otter, L; Arimont, M; Kidd, SL; Vidal, D; Dale, JW; Mervin, L; Sore, HF; Mateu, N; Lakshminarayana, N; Dawson, LA; Carlton, M; Bürli, RW Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators. Bioorg Med Chem Lett 61:0 (2022) [PubMed] 
Target
Name:
G-protein coupled receptor 39
Synonyms:
GPR39 | GPR39_HUMAN
Type:
PROTEIN
Mol. Mass.:
51351.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107977
Residue:
453
Sequence:
MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
  
Inhibitor
Name:
BDBM50596614
Synonyms:
CHEMBL5182651
Type:
Small organic molecule
Emp. Form.:
C19H16FN5
Mol. Mass.:
333.3622
SMILES:
Cc1cc(NCc2ccc(F)cc2)n2ncc(-c3ccccn3)c2n1
Structure:
Search PDB for entries with ligand similarity: