Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50174120
Substrate
n/a
Meas. Tech.
ChEMBL_326878 (CHEMBL862979)
Ki
460±n/a nM
Citation
 Grunewald, GL; Lu, J; Criscione, KR; Okoro, CO Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity. Bioorg Med Chem Lett 15:5319-23 (2005) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM50174120
Synonyms:
(R)-7-chloro-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline | CHEMBL197019
Type:
Small organic molecule
Emp. Form.:
C10H9ClF3N
Mol. Mass.:
235.633
SMILES:
FC(F)(F)[C@H]1Cc2ccc(Cl)cc2CN1
Structure:
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