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Target
D(2) dopamine receptor
Ligand
BDBM50181443
Substrate
n/a
Meas. Tech.
ChEMBL_331204 (CHEMBL864055)
IC50
>30000±n/a nM
Citation
 Buchstaller, HP; Siebert, CD; Steinmetz, R; Frank, I; Berger, ML; Gottschlich, R; Leibrock, J; Krug, M; Steinhilber, D; Noe, CR Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem 49:864-71 (2006) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50181443
Synonyms:
3-(2-aminoethyl)-2-chloro-4-hydroxy-5-(3-phenoxyphenyl)thieno[2,3-b]pyridin-6(7H)-one | CHEMBL202126
Type:
Small organic molecule
Emp. Form.:
C21H17ClN2O3S
Mol. Mass.:
412.889
SMILES:
NCCc1c(Cl)sc2[nH]c(=O)c(c(O)c12)-c1cccc(Oc2ccccc2)c1
Structure:
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