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Target
Mitogen-activated protein kinase 1
Ligand
BDBM50601917
Substrate
n/a
Meas. Tech.
ChEMBL_2238584 (CHEMBL5152480)
Kd
380±n/a nM
Citation
 Fu, L; Chen, S; He, G; Chen, Y; Liu, B Targeting Extracellular Signal-Regulated Protein Kinase 1/2 (ERK1/2) in Cancer: An Update on Pharmacological Small-Molecule Inhibitors. J Med Chem 65:13561-13573 (2022) [PubMed] 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM50601917
Synonyms:
CHEMBL5180873
Type:
Small organic molecule
Emp. Form.:
C44H80BrN19
Mol. Mass.:
955.137
SMILES:
NC(=N)NCCC[C@H]1CNC(=N)N1CCN(CCN1C[C@H](CCCNC(N)=N)N(CCCC2CCCCC2)C1=N)CCN1C[C@H](CCCNC(N)=N)N(CCc2cccc(Br)c2)C1=N |r|
Structure:
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