Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Ligand
BDBM50190564
Substrate
n/a
Meas. Tech.
ChEMBL_373621 (CHEMBL869761)
Ki
1300±n/a nM
Citation
 Nguyen, C; Ruda, GF; Schipani, A; Kasinathan, G; Leal, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Sahlberg, BL; Johansson, NG; Gonzalez-Pacanowska, D; Gilbert, IH Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem 49:4183-95 (2006) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Synonyms:
dUTP pyrophosphatase
Type:
Protein
Mol. Mass.:
19574.43
Organism:
Plasmodium falciparum
Description:
Q8II92
Residue:
173
Sequence:
MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKSNYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAALDNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
  
Inhibitor
Name:
BDBM50190564
Synonyms:
1-[4-acetyloxy-3-(tritylaminomethyl)butyl]uracil | CHEMBL208621
Type:
Small organic molecule
Emp. Form.:
C30H31N3O4
Mol. Mass.:
497.5848
SMILES:
CC(=O)OCC(CCn1ccc(=O)[nH]c1=O)CNC(c1ccccc1)(c1ccccc1)c1ccccc1
Structure:
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