Reaction Details Report a problem with these data
Target
Monoacylglycerol lipase ABHD6
Ligand
BDBM50211257
Substrate
n/a
Meas. Tech.
ChEMBL_2274342
IC50
2.8±n/a nM
Citation
 Deng, H; Li, W Therapeutic potential of targeting ?/?-Hydrolase domain-containing 6 (ABHD6). Eur J Med Chem 198:0 (2020) [PubMed] 
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6
Type:
PROTEIN
Mol. Mass.:
38341.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105457
Residue:
337
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
  
Inhibitor
Name:
BDBM50211257
Synonyms:
CHEMBL3895863 | US10583137, Compound 14
Type:
Small organic molecule
Emp. Form.:
C31H28F2N4O3
Mol. Mass.:
542.5758
SMILES:
OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1 |r|
Structure:
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