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Target
Kappa-type opioid receptor
Ligand
BDBM50519927
Substrate
n/a
Meas. Tech.
ChEMBL_2275978
Ki
649±n/a nM
Citation
 Chakraborty, S; Uprety, R; Slocum, ST; Irie, T; Le Rouzic, V; Li, X; Wilson, LL; Scouller, B; Alder, AF; Kruegel, AC; Ansonoff, M; Varadi, A; Eans, SO; Hunkele, A; Allaoa, A; Kalra, S; Xu, J; Pan, YX; Pintar, J; Kivell, BM; Pasternak, GW; Cameron, MD; McLaughlin, JP; Sames, D; Majumdar, S Oxidative Metabolism as a Modulator of Kratom's Biological Actions. J Med Chem 64:16553-16572 (2021) [PubMed] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
KOR-1 | MSL-1 | OPIATE Kappa | OPRK_MOUSE | Oprk1
Type:
Enzyme
Mol. Mass.:
42656.78
Organism:
Mus musculus (Mouse)
Description:
P33534
Residue:
380
Sequence:
MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
  
Inhibitor
Name:
BDBM50519927
Synonyms:
CHEMBL4546925
Type:
Small organic molecule
Emp. Form.:
C23H30N2O4
Mol. Mass.:
398.4953
SMILES:
[H][C@]12C[C@@H]([C@H](CC)CN1CCc1c2[nH]c2cccc(OC)c12)C(=C/OC)\C(=O)OC |r|
Structure:
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