Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 2
Ligand
BDBM50197024
Substrate
n/a
Meas. Tech.
ChEMBL_453177 (CHEMBL902327)
Ki
670±n/a nM
Citation
 DeCarr, LB; Buckholz, TM; Coish, PD; Fathi, Z; Fisk, SE; Mays, MR; O'Connor, SJ; Lumb, KJ Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett 17:538-41 (2007) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 2
Synonyms:
NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42734.65
Organism:
Homo sapiens (Human)
Description:
NPY-Y2 NPY2R HUMAN::P49146
Residue:
381
Sequence:
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
  
Inhibitor
Name:
BDBM50197024
Synonyms:
AcPYY(26-36) | CHEMBL397527
Type:
Small organic molecule
Emp. Form.:
C68H106N22O17
Mol. Mass.:
1503.7064
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:57.58,20.28,75.76,42.43,58.61,95.96,4.4,wD:34.35,8.17,64.65,50.51,84.85,(4.82,1.3,;4.82,-.24,;6.15,-1.01,;3.49,-1.01,;3.49,-2.55,;2.16,-3.32,;.82,-2.55,;.82,-1.01,;-.51,-3.32,;-.51,-4.86,;.82,-5.63,;2.16,-4.86,;3.49,-5.63,;3.49,-7.17,;4.81,-7.94,;2.16,-7.94,;.82,-7.17,;-1.84,-2.56,;-3.17,-3.34,;-3.17,-4.88,;-4.5,-2.57,;-4.5,-1.03,;-3.17,-.26,;-1.76,-.89,;-.73,.26,;-1.5,1.59,;-3.01,1.27,;-5.84,-3.32,;-7.17,-2.55,;-8.5,-3.32,;-7.17,-1.01,;4.82,-3.32,;4.82,-4.86,;6.15,-2.54,;7.48,-3.31,;7.48,-4.85,;8.81,-5.62,;10.13,-4.84,;8.81,-7.16,;8.81,-2.54,;8.81,-1,;10.15,-3.31,;11.48,-2.55,;11.48,-1.01,;12.81,-.24,;12.81,1.3,;14.15,-1.01,;12.81,-3.32,;12.81,-4.86,;14.14,-2.54,;15.48,-3.32,;15.48,-4.86,;16.8,-5.63,;14.14,-5.63,;16.8,-2.55,;16.8,-1.01,;18.14,-3.32,;19.48,-2.55,;19.48,-1.01,;18.14,-.24,;20.81,-.23,;20.81,-3.32,;20.81,-4.86,;22.14,-2.54,;23.47,-3.31,;23.47,-4.85,;24.8,-5.62,;24.8,-7.16,;26.13,-7.92,;26.13,-9.46,;24.8,-10.23,;27.47,-10.23,;24.8,-2.54,;24.8,-1,;26.13,-3.31,;27.47,-2.54,;27.47,-1,;28.8,-.23,;28.8,1.31,;27.47,2.08,;30.14,2.08,;28.8,-3.31,;28.8,-4.85,;30.13,-2.54,;31.47,-3.31,;31.47,-4.85,;32.79,-5.62,;32.79,-7.16,;34.13,-7.93,;34.13,-9.47,;32.79,-10.23,;35.46,-10.23,;32.79,-2.54,;32.79,-1,;34.13,-3.31,;35.46,-2.54,;35.46,-1,;36.79,-.23,;38.13,-1,;39.47,-.23,;39.47,1.31,;40.79,2.08,;38.13,2.08,;36.79,1.31,;36.79,-3.31,;38.13,-2.54,;36.79,-4.85,)|
Structure:
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