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Target
Transthyretin
Ligand
BDBM50609725
Substrate
n/a
Meas. Tech.
ChEMBL_2279405
Kd
26±n/a nM
Citation
 Mizuguchi, M; Nakagawa, Y; Inui, K; Katayama, W; Sawai, Y; Shimane, A; Kitakami, R; Okada, T; Nabeshima, Y; Yokoyama, T; Kanamitsu, K; Nakagawa, S; Toyooka, N Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J Med Chem 65:16218-16233 (2022) [PubMed] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50609725
Synonyms:
CHEMBL5280970
Type:
Small organic molecule
Emp. Form.:
C15H10Cl2O4
Mol. Mass.:
325.143
SMILES:
Oc1ccc2C(=O)CC(Oc2c1)c1cc(Cl)c(O)c(Cl)c1
Structure:
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