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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50205858
Substrate
n/a
Meas. Tech.
ChEMBL_428466 (CHEMBL918967)
Ki
36±n/a nM
Citation
 Wacker, DA; Varnes, JG; Malmstrom, SE; Cao, X; Hung, CP; Ung, T; Wu, G; Zhang, G; Zuvich, E; Thomas, MA; Keim, WJ; Cullen, MJ; Rohrbach, KW; Qu, Q; Narayanan, R; Rossi, K; Janovitz, E; Lehman-McKeeman, L; Malley, MF; Devenny, J; Pelleymounter, MA; Miller, KJ; Robl, JA Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor. J Med Chem 50:1365-79 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50205858
Synonyms:
(R)-9-ethyl-8-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one | CHEMBL374436
Type:
Small organic molecule
Emp. Form.:
C14H18N2O2
Mol. Mass.:
246.3049
SMILES:
CCc1cc2[C@@H]3CNCCN3C(=O)c2cc1OC
Structure:
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