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Target
Cyclin-dependent kinase 1
Ligand
BDBM50212021
Substrate
n/a
Meas. Tech.
ChEMBL_444510 (CHEMBL894747)
IC50
470±n/a nM
Citation
 Hughes, TV; Emanuel, SL; Beck, AK; Wetter, SK; Connolly, PJ; Karnachi, P; Reuman, M; Seraj, J; Fuentes-Pesquera, AR; Gruninger, RH; Middleton, SA; Lin, R; Davis, JM; Moffat, DF 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett 17:3266-70 (2007) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM50212021
Synonyms:
2-(4-(2-hydroxyethyl)phenylamino)-4-(thiophen-2-yl)pyrimidine-5-carbonitrile | CHEMBL245174
Type:
Small organic molecule
Emp. Form.:
C17H14N4OS
Mol. Mass.:
322.384
SMILES:
OCCc1ccc(Nc2ncc(C#N)c(n2)-c2cccs2)cc1
Structure:
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