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Target
Sialidase-4
Ligand
BDBM50229628
Substrate
n/a
Meas. Tech.
ChEMBL_461857 (CHEMBL927850)
IC50
>1000000±n/a nM
Citation
 Magesh, S; Moriya, S; Suzuki, T; Miyagi, T; Ishida, H; Kiso, M Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1). Bioorg Med Chem Lett 18:532-7 (2008) [PubMed]  Article 
Target
Name:
Sialidase-4
Synonyms:
NEU4 | NEUR4_HUMAN | Sialidase 4
Type:
PROTEIN
Mol. Mass.:
51579.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960637
Residue:
484
Sequence:
MGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGTLAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGCCWPS
  
Inhibitor
Name:
BDBM50229628
Synonyms:
(4S,5R,6R)-5-acetamido-6-((1S,2S)-1,2-dihydroxy-3-(3-methylpentanamido)propyl)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid | CHEMBL403931
Type:
Small organic molecule
Emp. Form.:
C17H28N2O8
Mol. Mass.:
388.4128
SMILES:
CCC(C)CC(=O)NC[C@H](O)[C@H](O)[C@@H]1OC(=C[C@H](O)[C@H]1NC(C)=O)C(O)=O |w:2.2,c:15|
Structure:
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