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Target
C-C chemokine receptor type 5
Ligand
BDBM50260106
Substrate
n/a
Meas. Tech.
ChEMBL_481407 (CHEMBL965944)
IC50
9000±n/a nM
Citation
 Yoganathan, K; Rossant, C; Glover, RP; Cao, S; Vittal, JJ; Ng, S; Huang, Y; Buss, AD; Butler, MS Inhibition of the human chemokine receptor CCR5 by variecolin and variecolol and isolation of four new variecolin analogues, emericolins A-D, from Emericella aurantiobrunnea. J Nat Prod 67:1681-4 (2004) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50260106
Synonyms:
CHEMBL519317 | Variecolin
Type:
Small organic molecule
Emp. Form.:
C25H36O2
Mol. Mass.:
368.5521
SMILES:
C[C@H]1CC(=O)[C@@H]2[C@H]1C[C@@]1(C)CC[C@]3(C)CC[C@@H]([C@H]3[C@@H]1C\C=C2\C=O)C(C)=C |r,c:23|
Structure:
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