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Target
Excitatory amino acid transporter 3
Ligand
BDBM50273238
Substrate
n/a
Meas. Tech.
ChEMBL_513717 (CHEMBL974567)
IC50
2460±n/a nM
Citation
 Mavencamp, TL; Rhoderick, JF; Bridges, RJ; Esslinger, CS Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3. Bioorg Med Chem 16:7740-8 (2008) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 3
Synonyms:
EAA3_HUMAN | EAAC1 | EAAT3 | Excitatory Amino Acid EAAT3 | HEAAC1 | SLC1A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57096.71
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT3 0 HUMAN::P43005
Residue:
524
Sequence:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
  
Inhibitor
Name:
BDBM50273238
Synonyms:
(S,S)-beta-3 Fluoro-Benzylaspartate | CHEMBL457411
Type:
Small organic molecule
Emp. Form.:
C11H12FNO4
Mol. Mass.:
241.2157
SMILES:
[NH3+][C@@H]([C@H](Cc1cccc(F)c1)C([O-])=O)C(O)=O |r|
Structure:
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