Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50244589
Substrate
n/a
Meas. Tech.
ChEMBL_512174 (CHEMBL968033)
EC50
1200±n/a nM
Citation
 Semple, G; Fioravanti, B; Pereira, G; Calderon, I; Uy, J; Choi, K; Xiong, Y; Ren, A; Morgan, M; Dave, V; Thomsen, W; Unett, DJ; Xing, C; Bossie, S; Carroll, C; Chu, ZL; Grottick, AJ; Hauser, EK; Leonard, J; Jones, RM Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem 51:5172-5 (2008) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50244589
Synonyms:
1-[6-(4-Methanesulfonyl-phenylamino)-5-nitro-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester | CHEMBL451797
Type:
Small organic molecule
Emp. Form.:
C19H23N5O6S
Mol. Mass.:
449.481
SMILES:
CCOC(=O)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: