Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50274690
Substrate
n/a
Meas. Tech.
ChEMBL_537241 (CHEMBL981856)
IC50
10±n/a nM
Citation
 Nagase, T; Mizutani, T; Sekino, E; Ishikawa, S; Ito, S; Mitobe, Y; Miyamoto, Y; Yoshimoto, R; Tanaka, T; Ishihara, A; Takenaga, N; Tokita, S; Sato, N Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists. J Med Chem 51:6889-901 (2008) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50274690
Synonyms:
CHEMBL521022 | cis-2-Methyl-3-(4-([4-(1-pyrrolidinyl)cyclohexyl]oxy)phenyl)-4(3H)-quinazolinone
Type:
Small organic molecule
Emp. Form.:
C25H29N3O2
Mol. Mass.:
403.5167
SMILES:
Cc1nc2ccccc2c(=O)n1-c1ccc(O[C@H]2CC[C@H](CC2)N2CCCC2)cc1 |r,wU:17.18,20.25,(13.81,-35.86,;12.48,-36.64,;11.14,-35.87,;9.81,-36.65,;8.47,-35.89,;7.15,-36.66,;7.14,-38.2,;8.48,-38.97,;9.82,-38.2,;11.15,-38.96,;11.15,-40.5,;12.49,-38.19,;13.82,-38.95,;13.82,-40.49,;15.15,-41.26,;16.49,-40.49,;17.82,-41.25,;19.15,-40.47,;19.14,-38.94,;20.47,-38.17,;21.81,-38.94,;21.81,-40.48,;20.48,-41.25,;23.14,-38.16,;24.55,-38.79,;25.58,-37.64,;24.81,-36.31,;23.3,-36.63,;16.48,-38.94,;15.14,-38.18,)|
Structure:
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