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Target
Cyclin-dependent kinase 2
Ligand
BDBM50246775
Substrate
n/a
Meas. Tech.
ChEMBL_557682 (CHEMBL962977)
IC50
7700±n/a nM
Citation
 Danilenko, VN; Simonov, AY; Lakatosh, SA; Kubbutat, MH; Totzke, F; Schächtele, C; Elizarov, SM; Bekker, OB; Printsevskaya, SS; Luzikov, YN; Reznikova, MI; Shtil, AA; Preobrazhenskaya, MN Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles. J Med Chem 51:7731-6 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50246775
Synonyms:
2-[3-(4,5-Dihydro-1H-imidazol-2-ylsulfanyl)propyl]-9b,10-dihydro-1Hindolo[1',7':4,5,6]pyrrolo[3',4':2,3][1,4]diazepino[1,7-a]indole-1,3(2H)-dione | CHEMBL488270
Type:
Small organic molecule
Emp. Form.:
C26H23N5O2S
Mol. Mass.:
469.558
SMILES:
O=C1N(CCCSC2=NCCN2)C(=O)C2=C1N1C(Cc3ccccc13)c1cccc3ccn2c13 |c:15,t:7|
Structure:
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