Reaction Details
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5-hydroxytryptamine receptor 1A
Ligand
BDBM50030009
Substrate
n/a
Meas. Tech.
ChEMBL_201036 (CHEMBL803262)
Ki
17±n/a nM
Citation
Liu, Y; Svensson, BE; Yu, H; Cortizo, L; Ross, SB; Lewander, T; Hacksell, U C8-substituted derivatives of 2-(dipropylamino)tetralin: Palladium-catalyzed synthesis and interactions with 5-HT1A-receptors Bioorg Med Chem Lett 1:257-262 (1991) Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
Inhibitor
Name:
BDBM50030009
Synonyms:
CHEMBL88157 | Dipropyl-(1,2,3,4-tetrahydro-naphthalen-2-yl)-amine | Dipropyl-(R)-1,2,3,4-tetrahydro-naphthalen-2-yl-amine
Type:
Small organic molecule
Emp. Form.:
C16H25N
Mol. Mass.:
231.3764
SMILES:
CCCN(CCC)[C@@H]1CCc2ccccc2C1
Structure:
