Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50280295
Substrate
n/a
Meas. Tech.
ChEBML_4306
IC50
2.8±n/a nM
Citation
 Hutchinson, JH; Prasit, P; Choo, LY; Riendeau, D; Charleson, S; Evans, JF; Piechuta, H; Ball, RG Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors Bioorg Med Chem Lett 2:1699-1702 (1992)    Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50280295
Synonyms:
3-[1-(4-Chloro-benzyl)-3-methyl-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid | CHEMBL31540
Type:
Small organic molecule
Emp. Form.:
C31H29ClN2O3
Mol. Mass.:
513.027
SMILES:
Cc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12
Structure:
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