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Target
Type-2 angiotensin II receptor
Ligand
BDBM50282427
Substrate
n/a
Meas. Tech.
ChEMBL_35440 (CHEMBL643800)
IC50
>50000±n/a nM
Citation
 Naylor, EM; Chakravarty, PK; Costello, CA; Chang, RS; Chen, TB; Faust, KA; Lotti, VJ; Kivlighn, SD; Zingaro, GJ; Siegl, PK; Wong, PC; Carini, DJ; Wexler, RR; Patchett, AA; Greenlee, WJ Potent imidazole angiotensinII antagonists: acyl sulfonamides and acyl sulfamides as tetrazole replacements Bioorg Med Chem Lett 4:69-74 (1994)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50282427
Synonyms:
2-Butyl-3-(2'-tetrazol-1-yl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methyl ester | CHEMBL422200
Type:
Small organic molecule
Emp. Form.:
C23H24N6O2
Mol. Mass.:
416.4757
SMILES:
CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Structure:
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