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Target
Prolyl endopeptidase
Ligand
BDBM50284617
Substrate
n/a
Meas. Tech.
ChEMBL_157473 (CHEMBL765792)
IC50
420±n/a nM
Citation
 Augustyns, K; Borloo, M; Belyaev, A; Rajan, P; Goossens, F; Hendriks, D; Scharpé, S; Haemers, A Synthesis of peptidyl acetals as inhibitors of prolyl endopeptidase Bioorg Med Chem Lett 5:1265-1270 (1995)    Article 
Target
Name:
Prolyl endopeptidase
Synonyms:
PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase
Type:
Enzyme
Mol. Mass.:
80688.50
Organism:
Homo sapiens (Human)
Description:
P48147
Residue:
710
Sequence:
MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
  
Inhibitor
Name:
BDBM50284617
Synonyms:
2-(2-[1,3]Dithiolan-2-yl-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester | CHEMBL23690
Type:
Small organic molecule
Emp. Form.:
C20H26N2O3S2
Mol. Mass.:
406.562
SMILES:
O=C(OCc1ccccc1)N1CCCC1C(=O)N1CCCC1C1SCCS1
Structure:
Search PDB for entries with ligand similarity: