Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50286165
Substrate
n/a
Meas. Tech.
ChEBML_49412
IC50
230±n/a nM
Citation
 Holladay, MW; Bennett, MJ; Bai, H; Ralston, JW; Kerwin, JF; Stashko, M; Miller, TR; O'Neill, AB; Nadzan, AM; Brioni, J; Lin, CW Amino acid-derived piperidides as novel CCKB ligands with anxiolytic-like properties Bioorg Med Chem Lett 5:3057-3062 (1995)    Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50286165
Synonyms:
1-{1-((R)-Benzyloxymethyl)-2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-3-m-tolyl-urea | CHEMBL102879
Type:
Small organic molecule
Emp. Form.:
C30H32FN3O4
Mol. Mass.:
517.5912
SMILES:
Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2)c1
Structure:
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