Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50297391
Substrate
n/a
Meas. Tech.
ChEMBL_583354 (CHEMBL1053347)
IC50
444±n/a nM
Citation
Hutchinson, JH; Li, Y; Arruda, JM; Baccei, C; Bain, G; Chapman, C; Correa, L; Darlington, J; King, CD; Lee, C; Lorrain, D; Prodanovich, P; Rong, H; Santini, A; Stock, N; Prasit, P; Evans, JF 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). J Med Chem 52:5803-15 (2009) [PubMed] Article
More Info.:
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
Inhibitor
Name:
BDBM50297391
Synonyms:
1-(Thiazol-2-yl)benzyl-3-[3-(cyclobutylcarbonyl)-5-(pyridine-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid | CHEMBL552544
Type:
Small organic molecule
Emp. Form.:
C34H33N3O4S
Mol. Mass.:
579.709
SMILES:
CC(C)(Cc1c(C(=O)C2CCC2)c2cc(OCc3ccccn3)ccc2n1Cc1ccc(cc1)-c1nccs1)C(O)=O