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Target
Sonic hedgehog protein
Ligand
BDBM50300854
Substrate
n/a
Meas. Tech.
ChEMBL_599200 (CHEMBL1049843)
IC50
1325±n/a nM
Citation
 Büttner, A; Seifert, K; Cottin, T; Sarli, V; Tzagkaroulaki, L; Scholz, S; Giannis, A Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem 17:4943-54 (2009) [PubMed]  Article 
Target
Name:
Sonic hedgehog protein
Synonyms:
Hhg1 | SHH_MOUSE | Shh
Type:
Protein
Mol. Mass.:
47784.50
Organism:
Mus musculus (Mouse)
Description:
Q62226
Residue:
437
Sequence:
MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPLGMAVKSS
  
Inhibitor
Name:
BDBM50300854
Synonyms:
CHEMBL583231 | N-(3-(1H-Benzo[d]imidazol-2-yl)phenyl)-3,4,5-triethoxybenzamide
Type:
Small organic molecule
Emp. Form.:
C26H27N3O4
Mol. Mass.:
445.5103
SMILES:
CCOc1cc(cc(OCC)c1OCC)C(=O)Nc1cccc(c1)-c1nc2ccccc2[nH]1
Structure:
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