Reaction Details Report a problem with these data
Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50323158
Substrate
n/a
Meas. Tech.
ChEMBL_643826 (CHEMBL1212690)
IC50
5000±n/a nM
Citation
Hong, Q; Bakshi, RK; Dellureficio, J; He, S; Ye, Z; Dobbelaar, PH; Sebhat, IK; Guo, L; Liu, J; Jian, T; Tang, R; Kalyani, RN; Macneil, T; Vongs, A; Rosenblum, CI; Weinberg, DH; Peng, Q; Tamvakopoulos, C; Miller, RR; Stearns, RA; Cashen, D; Martin, WJ; Chen, AS; Metzger, JM; Chen, HY; Strack, AM; Fong, TM; Maclntyre, E; Van der Ploeg, LH; Wyvratt, MJ; Nargund, RP Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands. Bioorg Med Chem Lett 20:4483-6 (2010) [PubMed] Article
More Info.:
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:
Enzyme
Mol. Mass.:
34717.23
Organism:
Homo sapiens (Human)
Description:
Q01726
Residue:
317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
Inhibitor
Name:
BDBM50323158
Synonyms:
CHEMBL1209382 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-4-methylpentyl)-N-isopropylmethane sulfonamide | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-4-methylpentyl)-N-isopropylmethanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C29H48F2N4O3S
Mol. Mass.:
570.778
SMILES:
CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r|