Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50329382
Substrate
n/a
Meas. Tech.
ChEMBL_675633 (CHEMBL1273941)
Ki
8000±n/a nM
Citation
 Petros, AM; Huth, JR; Oost, T; Park, CM; Ding, H; Wang, X; Zhang, H; Nimmer, P; Mendoza, R; Sun, C; Mack, J; Walter, K; Dorwin, S; Gramling, E; Ladror, U; Rosenberg, SH; Elmore, SW; Fesik, SW; Hajduk, PJ Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. Bioorg Med Chem Lett 20:6587-91 (2010) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50329382
Synonyms:
3'-(2-(4-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)phenoxy)ethyl)biphenyl-4-carboxylic acid | CHEMBL1271231
Type:
Small organic molecule
Emp. Form.:
C33H35NO4
Mol. Mass.:
509.6353
SMILES:
CN(C)CCCC(O)(c1ccccc1)c1ccc(OCCc2cccc(c2)-c2ccc(cc2)C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: