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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50342685
Substrate
n/a
Meas. Tech.
ChEMBL_745194 (CHEMBL1772425)
EC50
45±n/a nM
Citation
 Szewczyk, JW; Acton, J; Adams, AD; Chicchi, G; Freeman, S; Howard, AD; Huang, Y; Li, C; Meinke, PT; Mosely, R; Murphy, E; Samuel, R; Santini, C; Yang, M; Zhang, Y; Zhao, K; Wood, HB Design of potent and selective GPR119 agonists for type II diabetes. Bioorg Med Chem Lett 21:2665-9 (2011) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_MOUSE | Gpr119
Type:
PROTEIN
Mol. Mass.:
37009.07
Organism:
Mus musculus
Description:
ChEMBL_1506420
Residue:
335
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
  
Inhibitor
Name:
BDBM50342685
Synonyms:
1-(5-methylpyrimidin-2-yl)-1'-(4-(methylsulfonyl)phenyl)-4,4'-bipiperidine | CHEMBL1771086
Type:
Small organic molecule
Emp. Form.:
C22H30N4O2S
Mol. Mass.:
414.564
SMILES:
Cc1cnc(nc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: