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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50348298
Substrate
n/a
Meas. Tech.
ChEMBL_757486 (CHEMBL1804458)
IC50
367±n/a nM
Citation
 Wang, H; Robl, JA; Hamann, LG; Simpkins, L; Golla, R; Li, YX; Seethala, R; Zvyaga, T; Gordon, DA; Li, JJ Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). Bioorg Med Chem Lett 21:4146-9 (2011) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50348298
Synonyms:
CHEMBL1800123
Type:
Small organic molecule
Emp. Form.:
C20H22ClN3O2
Mol. Mass.:
371.861
SMILES:
Cc1c(Cl)cccc1Oc1cccn2c(nnc12)C1CCC(C)(O)CC1 |(2.2,-13.08,;2.25,-14.62,;.94,-15.43,;-.41,-14.7,;.99,-16.97,;2.36,-17.7,;3.66,-16.88,;3.61,-15.35,;4.93,-14.56,;6.27,-15.33,;6.27,-16.87,;7.63,-17.62,;8.94,-16.85,;8.93,-15.32,;10.07,-14.29,;9.43,-12.88,;7.89,-13.04,;7.6,-14.55,;11.57,-14.6,;12.05,-16.07,;13.55,-16.38,;14.58,-15.23,;15.91,-15.99,;15.91,-14.45,;14.1,-13.77,;12.59,-13.45,)|
Structure:
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